na INLIS000000000018754 20240207031859 0010-0224000004 ta 240207 | | | ARTVET2380 Blacksell, Stuart D. The Biosafety Research Road Map : The Search for Evidence to Support Practices in the Laboratory—Mpox/Monkeypox Virus / Blacksell, Stuart D. Applied Biosafety, Vol, 28, No, 3 2023 152-161 mpox virus mpox pathogen characteristics biosafety evidence biosafety knowledge gaps Dhawan, Sandhya Kusumoto, Marina Le, Kim Khanh Summermatter, Kathrin O’Keefe, Joseph Kozlovac, Joseph Muhairi, Salama Suhail Al Sendow, Indrawati Scheel, Christina M. Ahumibe, Anthony Masuku, Zibusiso M. Bennett, Allan M. Kojima, Kazunobu Harper, David R. Hamilton, Keith Introduction: The virus formerly known as monkeypox virus, now called mpoxv, belongs to the Orthopox- virus genus and can cause mpox disease through both animal-to-human and human-to-human transmis- sion. The unexpected spread of mpoxv among humans has prompted the World Health Organization (WHO) to declare a Public Health Emergency of International Concern (PHEIC). Methods: We conducted a literature search to identify the gaps in biosafety, focusing on ?ve main areas: how the infection enters the body and spreads, how much of the virus is needed to cause infection, infections acquired in the lab, accidental release of the virus, and strategies for disinfecting and decontaminating the area. Discussion: The recent PHEIC has shown that there are gaps in our knowledge of biosafety when it comes to mpoxv. We need to better understand where this virus might be found, how much of it can spread from person-to-person, what are the effective control measures, and how to safely clean up contaminated areas. By gathering more biosafety evidence, we can make better decisions to protect people from this zoonotic agent, which has recently become more common in the human population. DOI: 10.1089/apb.2022.0045 ARTVET2380