The Search for Evidence to Support Practices in the Laboratory—Zoonotic Avian In?uenza and Mycobacterium tuberculosis Blacksell, Stuart D. text 2023 Applied Biosafety, Vol, 28, No, 3

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135–151 Abstract Introduction: The Biosafety Research Road Map reviewed the scienti?c literature on a viral respiratory path- ogen, avian in?uenza virus, and a bacterial respiratory pathogen, Mycobacterium tuberculosis. This project aims at identifying gaps in the data required to conduct evidence-based biorisk assessments, as described in Blacksell et al. One signi?cant gap is the need for de?nitive data on M. tuberculosis sample aerosolization to guide the selection of engineering controls for diagnostic procedures. Methods: The literature search focused on ?ve areas: routes of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination methods. Results: The available data regarding biosafety knowledge gaps and existing evidence have been collated and presented in Tables 1 and 2. The guidance sources on the appropriate use of biosafety cabinets for spe- ci?c procedures with M. tuberculosis require clari?cation. Detecting vulnerabilities in the biorisk assessment for respiratory pathogens is essential to improve and develop laboratory biosafety in local and national systems.Abstract Introduction: The Biosafety Research Road Map reviewed the scienti?c literature on a viral respiratory path- ogen, avian in?uenza virus, and a bacterial respiratory pathogen, Mycobacterium tuberculosis. This project aims at identifying gaps in the data required to conduct evidence-based biorisk assessments, as described in Blacksell et al. One signi?cant gap is the need for de?nitive data on M. tuberculosis sample aerosolization to guide the selection of engineering controls for diagnostic procedures. Methods: The literature search focused on ?ve areas: routes of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination methods. Results: The available data regarding biosafety knowledge gaps and existing evidence have been collated and presented in Tables 1 and 2. The guidance sources on the appropriate use of biosafety cabinets for spe- ci?c procedures with M. tuberculosis require clari?cation. Detecting vulnerabilities in the biorisk assessment for respiratory pathogens is essential to improve and develop laboratory biosafety in local and national systems. Blacksell, Stuart D. Mycobacterium tuberculosis pathogen characteristics biosafety evidence biosafety knowledge gap Zoonotic avian in?uenza ARTVET2379 240207 20240207031818 INLIS000000000018753 Converted from MARCXML to MODS version 3.5 using MARC21slim2MODS3-5.xsl (Revision 1.106 2014/12/19)