02294     2200217   4500001002100000005001500021035002000036007000300056008003900059082001500098084001500113100002200128245007100150250001800221260005600239300000600295650003200301700002500333520170200358990001602060INLIS00000000001910220240910123959  a0010-0924000181ta240910                |          | |    aARTVET1669  aARTVET16690 aDYAH AYU HEWAJULI1 aPATOGENITAS VIRUS NEWCASTLE DISEASE PADA AYAM /cDYAH AYU HEWAJULI  aVol. 21 No. 2  aBalai Besar Penelitian Veteriner :bWARTAZOA,c2011  a9 4aPATOGENITAS VIRUS NEWCASTLE0 aN.L.P.I. DHARMAYANTI  aNewcastle disease (ND) is one of the highly infectious diseases in poultry industry. Newcastle disease causes high 
morbidity and mortality in birds, then it causes significant loss for poultry industry. This disease is caused by Avian 
paramyxovirus-1, included in the genus of Avulavirus and family of Paramyxoviridae. This virus has six prior proteins and two 
non structural proteins that evolving its genom. Those proteins are Nucleocapsid protein (N), Phosphoprotein (P), Matrix protein 
M), Fusion protein (F), Hemagglutinin-neuraminidase protein (HN) and Large polymerase protein (L) and two non structural 
proteins iVe and W protein which are produced during the transcriptation process of P gen on editing process. Each of the protein 
has a specific role that responsible for the virulence of the virus. The previous result showed that HN and F proteins have 
significant contribution in the virulence and spreading of ND virus in the hosts. Virulence of ND virus primarily is determined by 
cleavage site of F protein, but the recent research showed that the cleavage site motiv of F0 protein is not the only factor to 
determine the virulence of ND virus. Besides F protein, other proteins also contribute patern to the virulence of ND virus. ND 
virus can infect more than 200 species of birds, but the severity level of the disease varies depending on the host and strain of ND 
virus. Chicken has the highest pathogenicity index compared to other birds. Generally, the immunity system in chicken against 
infection of ND virus is similar to the immunity system of other birds. Cell mediated and humoral immunity responses play an 
important role in overcome ND virus.  a00000033118