The Search for Evidence to Support Practices in the Laboratory—SARS-CoV-2 Blacksell, Stuart D. text 2023 Applied Biosafety, Vol, 28, No, 2.

text

regular print

87–95 Introduction: The SARS-CoV-2 virus emerged as a novel virus and is the causative agent of the COVID-19 pandemic. It spreads readily human-to-human through droplets and aerosols. The Biosafety Research Roadmap aims to support the application of laboratory biological risk management by providing an evi- dence base for biosafety measures. This involves assessing the current biorisk management evidence base, identifying research and capability gaps, and providing recommendations on how an evidence- based approach can support biosafety and biosecurity, including in low-resource settings. Methods: A literature search was conducted to identify potential gaps in biosafety and focused on ?ve main sections, including the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies. Results: There are many knowledge gaps related to biosafety and biosecurity due to the SARS-CoV-2 virus’s novelty, including infectious dose between variants, personal protective equipment for personnel handling samples while performing rapid diagnostic tests, and laboratory-acquired infections. Detecting vulnerabil- ities in the biorisk assessment for each agent is essential to contribute to the improvement and develop- ment of laboratory biosafety in local and national systems. Blacksell, Stuart D. SARS-CoV-2 pathogen characteristics biosafety evidence biosafety knowledge gap biorisk management ARTVET2383 ARTVET2383 240212 20240212081818 INLIS000000000018757 Converted from MARCXML to MODS version 3.5 using MARC21slim2MODS3-5.xsl (Revision 1.106 2014/12/19)