The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis Blacksell, Stuart D. text 2023 Applied Biosafety, Vol, 28, No, 2.

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72–86 Introduction: Brucella melitensis and Bacillus anthracis are zoonoses transmitted from animals and animal products. Scienti?c information is provided in this article to support biosafety precautions necessary to protect laboratory workers and individuals who are potentially exposed to these pathogens in the workplace or other settings, and gaps in information are also reported. There is a lack of information on the appropriate effective concentration for many chemical disinfectants for this agent. Controversies related to B. anthracis include infectious dose for skin and gastrointestinal infections, proper use of personal protective equipment (PPE) during the slaughter of infected animals, and handling of contaminated materials. B. melitensis is reported to have the highest number of laboratory-acquired infections (LAIs) to date in laboratory workers. Methods: A literature search was conducted to identify potential gaps in biosafety and focused on ?ve main sections including the route of inoculation/modes of transmission, infectious dose, LAIs, containment releases, and disinfection and decontamination strategies. Results: Scienti?c literature currently lacks information on the effective concentration of many chemical dis- infectants for this agent and in the variety of matrices where it may be found. Controversies related to Blacksell, Stuart D. Bacillus anthracis Brucella melitensis pathogen characteristics biosafety evidence biosafety knowledge gap ARTVET2382 ARTVET2382 240207 20240207031934 INLIS000000000018756 Converted from MARCXML to MODS version 3.5 using MARC21slim2MODS3-5.xsl (Revision 1.106 2014/12/19)