The Search for Evidence to Support Practices in Human and Veterinary Laboratories Blacksell, Stuart D. text 2023 Applied Biosafety, Vol, 28, No, 2.

text

regular print

64–71 Introduction: Lack of evidence-based information regarding potential biological risks can result in inappro- priate or excessive biosafety and biosecurity risk-reduction strategies. This can cause unnecessary damage and loss to the physical facilities, physical and psychological well-being of laboratory staff, and community trust. A technical working group from the World Organization for Animal Health (WOAH, formerly OIE), World Health Organization (WHO), and Chatham House collaborated on the Biosafety Research Roadmap (BRM) project. The goal of the BRM is the sustainable implementation of evidence-based biorisk manage- ment of laboratory activities, particularly in low-resource settings, and the identi?cation of gaps in the cur- rent biosafety and biosecurity knowledge base. Methods: A literature search was conducted for the basis of laboratory design and practices for four selected high-priority subgroups of pathogenic agents. Potential gaps in biosafety were focused on ?ve main sections, including the route of inoculation/modes of transmission, infectious dose, laboratory- acquired infections, containment releases, and disinfection and decontamination strategies. Categories rep- resenting miscellaneous, respiratory, bioterrorism/zoonotic, and viral hemorrhagic fever pathogens were created within each group were selected for review. Blacksell, Stuart D. biosafety gap bioterrorism/zoonotic pathogens miscellaneous pathogens respiratory pathogens viral hemor- rhagic fevers ARTVET2381 ARTVET2381 240207 20240207031918 INLIS000000000018755 Converted from MARCXML to MODS version 3.5 using MARC21slim2MODS3-5.xsl (Revision 1.106 2014/12/19)