02669     2200433   4500001002100000005001500021007000300036008003900039020001500078035002000093084001500113100002500128245014500153250003900298260000900337300001200346520137400358650001801732650003601750650002801786650002601814650003101840700002101871700002901892700002201921700002001943700002001963700002101983700002102004700002102025700002102046700001802067700002402085700002202109700002502131700002202156700002602178856003102204INLIS00000000001875520240207031918ta240207                |          | |    aARTVET2381  a0010-0224000005  aARTVET23810 aBlacksell, Stuart D.1 aThe Biosafety Research Road Map :bThe Search for Evidence to Support Practices in Human and Veterinary Laboratories /cBlacksell, Stuart D.  aApplied Biosafety, Vol, 28, No, 2.  c2023  a64–71  aIntroduction: Lack of evidence-based information regarding potential biological risks can result in inappro-
priate or excessive biosafety and biosecurity risk-reduction strategies. This can cause unnecessary damage
and loss to the physical facilities, physical and psychological well-being of laboratory staff, and community
trust. A technical working group from the World Organization for Animal Health (WOAH, formerly OIE),
World Health Organization (WHO), and Chatham House collaborated on the Biosafety Research Roadmap
(BRM) project. The goal of the BRM is the sustainable implementation of evidence-based biorisk manage-
ment of laboratory activities, particularly in low-resource settings, and the identi?cation of gaps in the cur-
rent biosafety and biosecurity knowledge base.
Methods: A literature search was conducted for the basis of laboratory design and practices for four
selected high-priority subgroups of pathogenic agents. Potential gaps in biosafety were focused on ?ve
main sections, including the route of inoculation/modes of transmission, infectious dose, laboratory-
acquired infections, containment releases, and disinfection and decontamination strategies. Categories rep-
resenting miscellaneous, respiratory, bioterrorism/zoonotic, and viral hemorrhagic fever pathogens were
created within each group were selected for review. 4abiosafety gap 4abioterrorism/zoonotic pathogens 4amiscellaneous pathogens 4arespiratory pathogens 4aviral hemor- rhagic fevers0 aAhumibe, Anthony0 aAlmuhairi, Salama Suhail0 aBennett, Allan M.0 aDhawan, Sandhya0 aHamilton, Keith0 aHarper, David R.0 aKojima, Kazunobu0 aKozlovac, Joseph0 aKusumoto, Marina0 aLe, Kim Khanh0 aMasuku, Zibusiso M.0 aO’Keefe, Joseph0 aScheel, Christina M.0 aSendow, Indrawati0 aSummermatter, Kathrin  aDOI: 10.1089/apb.2022.0040