The Search for Evidence to Support Practices in the Laboratory—Mpox/Monkeypox Virus Blacksell, Stuart D. text 2023 Applied Biosafety, Vol, 28, No, 3

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152-161 Introduction: The virus formerly known as monkeypox virus, now called mpoxv, belongs to the Orthopox- virus genus and can cause mpox disease through both animal-to-human and human-to-human transmis- sion. The unexpected spread of mpoxv among humans has prompted the World Health Organization (WHO) to declare a Public Health Emergency of International Concern (PHEIC). Methods: We conducted a literature search to identify the gaps in biosafety, focusing on ?ve main areas: how the infection enters the body and spreads, how much of the virus is needed to cause infection, infections acquired in the lab, accidental release of the virus, and strategies for disinfecting and decontaminating the area. Discussion: The recent PHEIC has shown that there are gaps in our knowledge of biosafety when it comes to mpoxv. We need to better understand where this virus might be found, how much of it can spread from person-to-person, what are the effective control measures, and how to safely clean up contaminated areas. By gathering more biosafety evidence, we can make better decisions to protect people from this zoonotic agent, which has recently become more common in the human population. Blacksell, Stuart D. mpox virus mpox pathogen characteristics biosafety evidence biosafety knowledge gaps ARTVET2380 ARTVET2380 240207 20240207031859 INLIS000000000018754 Converted from MARCXML to MODS version 3.5 using MARC21slim2MODS3-5.xsl (Revision 1.106 2014/12/19)