02417     2200193   4500001002100000005001500021035002000036245022500056700002200281700005500303250003700358260000900395300002100404084001500425082001500440008003900455520171400494990001502208INLIS00000000001746020241112122233  a0010-0721001992  aEfikasi Penerapan Vaksin AI H5N1 Clade 2.1.3 pada Itik Mojosari Terhadap Tantangan Virus AI H5N1 Clade 2.3.2 pada Kondisi Laboratorium /cIndriani, R; Dharmayanti, NLPI; Adjid, R. M. A. (Balai Besar Penelitian Veteriner)  aDharmayanti, NLPI  aAdjid, R. M. A. (Balai Besar Penelitian Veteriner)  aJurnal Ilmu Ternak dan Veteriner  c2014  aVol.19 (1). 2014  aARTVET1992  aARTVET1992241112                |          | |    aIndriani R, Dharmayanti NLPI, Adjid RMA. 2014. Efficacy of application of vaccine AI H5N1 clade 2.1.3 on Mojosari ducks
challenge against AI H5N1 clade 2.3.2 in laboratory conditions. JITV 19(1): 59-66. DOI: http://dx.doi.org/10.14334/jitv.
v19i1.995
Influenza virus HPAI H5N1 clade 2.3.2 outbreaks since September 2012 caused high mortality in ducks. Vaccination is one
of strategies recommended by government. However, AI H5N1 clade 2.3.2 vaccine not yet available during this research, while
AI H5N1 clade 2.1.3 vaccines available in markets. Therefore it was important to do study on efficay of HPAI H5N1 clade
2.1.3. vaccines on duck at laboratory scale. Three groups of Mojosari duck were used in this study, they were 1 group vaccinated
with A Vaccine, 1 group vaccinated with B Vaccine, and 1 group as control (not vaccinated). Vacination groups consisted of 9
DOD and control group was consisted of 6 DOD. Vaccination was conducted when the duck at three weeks old of age using
single dose recommended by producer. At three weeks later (ducks at 6 weeks old of age) all Groups of ducks were challenged
with virus HPAI H5N1 clade 2.3.2 at dose 106 EID50/ml by drops intranasaly. Result showed that Group 1 (vaccinated with A
Vaccine) produced 67% protection (3 out of 9 ducks died), Group 2 (vaccinated with B Vaccine) produced 100% protection (non
out of 9 ducks died), and Group 3 (control, not vaccinated) produce 0% protection (all of 9 ducks died). This study give an
alternative of choise to use AI H5N1 Clade 2.1.3 vaccine with high protection when AI H5N1 Clade 2.3.2 vaccine not available
in markets to controll high mortality in ducks caused by HPAI H5N1 clade 2.3.2 outbreaks.  aARTVET1992