01826     2200229   4500001002100000005001500021035002000036008004100056020001400097041000700111082000900118090002600127100005900153700002500212700002900237245014600266250001800412260002900430500103900459650007201498990002601570INLIS00000000001432520240215075535  a0010-0521014325240215                |          |        a0147-9571  aen  aNONE  acimid-vol.36-2013-4490 aGröne, Andrea0 aAllaart,  Janneke G.0 avan Asten, Alphons J.A.M1 aPredisposing factors and prevention of Clostridium perfringens-associated enteritis /cGröne, Andrea  aVol.36 (2013)  a[s.l] :bElsevier,c2013  aClostridium perfringens is one of the major causes of intestinal disease in humans and animals. Its pathogenicity is contributed to by the production of a variety of toxins. In addition, predisposing environmental factors are important for the induction of C. perfringensassociated enteritis as shown by infection models. Environmental contamination, gastric and intestinal pH, intestinal microflora, nutrition, concurrent infections, and medical interventions may influence the intestinal colonization, growth, and toxin production by C.perfringens. Prevention of C. perfringens-associated enteritis may be mediated by the use of feed additives like probiotics, prebiotics, organic acids, essential oils, bacteriophages,lysozymes, bacteriocins, and antimicrobial peptides. Here we summarize and discuss published data on the influence of different environmental predisposing factors and preventive measures. Further research should focus on feed composition and feed additives in order to prevent C. perfringens-associated enteritis. 4aCLOSTRIDIUM PERFRINGENS -- NUTRITION -- FEED ADDITIVES -- ENTERITIS  acimid-vol.36-2013-449